If you like picking off enemies from afar, then Despair and Ballistica (yes, Ballistica) are very good options. Ballistica's projectiles are very fast and accurate, have no dropoff, and are perhaps the most reliable way of OHK'ing enemies past medium distance besides using Lanka or Miter (or Primed Chamber Vectis). It's a near-direct upgrade to Bows, with its ridiculously fast charge speed, near-nonexistent cooldown, and higher minimum, average, and maximum charged damage than what any Bow can accomplish.
Despair is much easier to use, infinitely better for crowd control, and an expert at mid-range combat, although it doesn't have quite the one-hit-kill-enemy-from-afar capabilities that Ballistica has (although, if you're good at angling, it can two-hit-kill-enemy-from-afar just as quickly).
Edited by SortaRandom, 11 January 2014 - 01:24 PM.