Adaptation has a max 90% damage reduction. Nidus needs his stacks. All I see are youtube videos of nidus with Octavian specters, because nidus is weaker without a buffer.
Inaros rage+Hunter Adrenaline= Scarab Swarm recovering tons of Energy. It also adds to armor cap of 100%. Remember that default 225? It now bigger. With just a max steel fiber it is 697.5. Scarb swarm when dispel refunds all health spent on it.
Nidus suffers from viral,heat,toxic and radiation damage the most. They are the most common ways to destroy him. I seen zero nidus used in the scarlet spear events. Nidus lacks proper offensive against sentinent enemies.
I have a challenge for you. See if the wisp boss can 1 shot your nidus. I want to see these mutation defense against the wisp boss. No sentinent or anti sentinent weapons.