You said that this system would be more story-inclusive and that the first Nightwave "The Wolf of Saturn Six" would be featuring a new villain for us to go up against.
If this works these Nightwaves would be perfect opportunities to expand on the already existing antagonists we have in the game!
Think about it: Lech Kril, Kela De Thaym, Tyl Regor, Vor, Frohd Bek. Many of the villains we have in the game are introduced once in an event and don't show up again until maybe a year and a half have passed, if at all.
I have no idea who Lech Kril is or why he exists despite being the first boss to ever get his own unique appearance and fight, Kela is kinda just there, and Tyl Regor is Tyl Regor and thus needs more screentime. Vor and (probably) Bek are both canonically dead so them not showing up again is excused.
Sargas Ruk, Alad V and Nef Anyo maybe less than the others since Alad had a major run as primary opponent (though i wouldn't mind him showing up again, maybe even as an ally for a Nightwave like in the Second Dream and Shadow Debt), Sargas Ruk shows up in more Events than any other Grineer (next to Vay Hek, but he's had enough appearances), and Nef Anyo has replaced Alad as our current main Corpus villain.
This is a huge opportunity guys. Don't just focus on the new, but remember to give the people you already have some love.