TL;DR a Sentient frame cannot feasibly work within the scope of the lore. I am a killjoy, yes.
The Void is poison to Sentients. It annihilates them merely by touch alone - this is why Sentient adaptation is reset by the Operator's void beam. Creating a -conduit- for the Void energy every Tenno possesses out of Sentient material would result in a living bomb the moment Transference engages. Unless there's a legion of Legions, well, you're not going to get very far.
"But what about Stalker?" Well, we still don't know if he's a Warframe or not, do we?