Any nullifier. We got an abilities as huge gameplay part, but some random enemy just jumps from the celling or from behind and "NOPE - you doesnt have this gameplay part now, and lets turn off all you got active", and also their shields soaking any damage, and that joke-like drone "just kill it to remove the bubble", good luck doing it when it is a bit behind the bubble and your hits wont reach it.
If as a enemy set - Orb Vallis because of huge variety of enemy abilities at once - you get insta-blobbed by stagger, crowd control, nulification, ability cancelling (general nullification and