I typically play my Zephyr and just unload my primary(Kuva Quartakk, Incarnon Boltor, Incarnon Burston) into their head and spam red crits till dead. That being said some do more quite fast and i have to either stop them myself or hope someone else does to get a chance to perforate their skulls.
If anything the annoying part is finding them in time. I had to change my sound settings to catch them, cause i used to play with lowered sound so i can listen to something in the background. So they sometimes get too close to the target to stop them, or someone activates another key and you have 2 running around ect.