"Continuity" in Warframe has always been confused, due to the very nature of the game. I mean, you have to write your lore in episodes, often disconnected between themselves because you must stick with gameplay reasons: can you blame them? For example, during Operation: Eyes of Blight (from 2014, introduction of Fomorians) Vay Hek was heavily scolded by the Twin Queens, who said he was about to be replaced by Tyl Regor. For something similar, Vor was degraded to Captain (from Admiral). Now, year 2021, we have seen Hek multiple times (last one at Tennocon) after that and never seemed to be degraded, he's still Councilor and in fact in charge of Earth (or at least the Plains of Eidolon). In fact that was soft-retconned, due to the fact we don't have anything even about some Regor's promotion. If we have similar problems about (supposedly lore-accurate) Operations, can we pretend normal missions to be lore-accurate? As for now, I think we just canonically killed: - Zanuka on Jupiter. After that Alad focused on Infestation, so we know lorewise Zanuka Project failed. - Vor on Ceres. Dunno about Lech Kril, but of course Vor canonically died and was resurrected as Corrupted by Janus Key. - Ropalolyst on Jupiter. We don't have a quest mention to it, but this particular Assassination mission is important lore-wise and Natah herself says Ropalolyst was expendable. - The Sergeant on Phobos. Of course, he's a random nobody 😅. Hope poor guy gets reworked, or at least replaced by John Prodman to go full meme. - Despite being a robot, technically we "killed" Ambulas for good after blowing up Bek's main ship, Ergo Glast strongly implies we stopped its production. To be honest we don't know anything about Kril's fate after Ceres, IIRC we never heard about him after that. But, you know, we already had an Assassination against him on Mars and it went "LOL JK never happened", so we can't really know if he's dead or alive. Others are alive: - Vay Hek is of course alive, only one that clearly escaped us. - Jackal, Raptors and Hyenas are robots, can be rebuilt. - Sargas Ruk is well alive (featured in multiple operations such as Scarlet Spear or even Pyrus Project, which was long after Eyes of Blight). - Tyl Regor is alive as well (featuring in Tubemen of Regor when Alad was messing with Infestation). - Kela de Thaym is alive as of Dog Days. Dunno about Infested bosses, other than of course Alad V.