Already many people have reported a problem with sanctuary collection. (I don't know the exact name of the quest because of a different localization).
The essence when you are given 3 waves to kill enemies.
And you have to collect 4 fragments for the shrine to be collected.
For 3 waves falls only 3 fragments, which is why the quest is broken and can not be continued. And you have to collect 4 fragments!
As a result, when such a quest is considered the main, then continue the mission is impossible.