For what it matters, at end game it's possible to make the game nearly play itself or to concoct a loadout that rewards skilled play with appreciable results. Personally, I have tuned my default build to allow me to effectively melee in sorties and still retain some possibility of dying, as I feel the threat of death is part of the fun. I am also attempting to develop a system of techniques to further my ability to engage enemies.
Ideally, if you keep researching and experiencing weapons, at some point you'll find a couple you enjoy using. I tend to dislike hitscan guns and CC intensive w