It's more the mental disconnect that's annoying
I can kill Corpus troopers fine in most missions with normal weapons, and Toxin works fine, but i don't have Venomous Clip for my archguns yet, and that's the weapon we're discussing.
For example, doing the Profit taker fight, the regular troopers that show up can sometimes take 30 seconds of Mausolon fire to die, shooting them directly in the face, because they apparently scale with the giant spider. It's not that i can't kill them, its that regular humans with no shields have no business tanking fire that happily destroys shielded fighters in space. I've had less issue cutting down Thrax and Void Angels with the same weapon than Joe Bloggs with a Reinforcement Beacon, so it seems like a scaling issue :D